The Effects of 4(3)quinazolinone-2-propyl-2-phenyl Ethyl on Brain Development of Newborn Balb/c Mice

Quinazolinones, water insoluble heterocyclic compounds, have various biological and pharmacological properties (anti-bacterial, anti-inflammation, sedation and anti-depression) are also used for the treatments of cancer and HIV. Our previous results proved that new derivative of quinazolinones is toxogenic and teratogenic in mouse. Pregnant Balb/C mice (n=8) were divided into 3 groups of control, receiving distilled water, sham,treated with 0.05% methyl cellulose (the solvent)and experimental group, receiving one of the most effective dose of 100mg/kg/body weight of 4(3H)quinazolinone-2propyl-2-phenyl ethyl (QPPE) by IP injections on days 8 to 15 of gestation. After anesthetizing, brains of 5-day old newborn Balb/C mice were removed and prepared for histopathological studies. Pathological observations demonstrated an increase in the number of astrocytes of cerebral cortex and medulla of newborn mice of treated groups. Confirming the results, statistical studies showed no significant differences between the morphology of newborn mice of control, sham and treated groups’astrocytes, but there were significant differences in the number of astrocytes of newborn mice of group treated with QPPE. In conclusion, astrocyte hyperplasia decreases toxic effects of QPPE by passing through blood-brain barrier.